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Comparison of kinetic parameters derived from the whole-brain two-compartment analysis

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Data are presented as median (1 quartile, 3 quartile) for each group.

*One rat in the prone group was excluded from analysis due to two-compartmental fitting failure of the whole-brain TSCs for unknown reasons.

Given that the overall delivery of Gd-DTPA from the CM into the brain was proven to be similar across the three groups ( Fig. 1 , Table 1 ) and whole-brain glymphatic transport/uptake ( V T ) (as well as regional uptake in the cerebellum, hippocampus, and midbrain) was reduced in the prone compared with the RLD position ( Davan LAUREN Ralph Lauren pEISTXCDBL
), we hypothesized that this might be attributed to alternate CSF efflux patterns in prone rats. For example, if a fraction of CSF is exiting “prematurely” along cranial nerves and/or neck large vessels from the CM when the brain is in a more upright position, this could explain why less CSF from the CM enters the brain of rats in prone position compared with other body positions. To test this hypothesis, we compared transport of Gd-DTPA associated with key CSF efflux pathways between the three body positions. The key ROIs for CSF efflux were identified on the anatomical MRIs and included the auditory nerve–cochlea complex ( Unoclya ALDO ke31nf
A–E ), point of exit of the vagus (X) nerve ( Tilden Free Clarks XZEqyVAsv
A , B , D ), area along the superior sagittal (SS) sinus ( Fig. 4 H , I ), and space along the internal carotid arteries (ICA; Fig. 4 A , F , G ). To enhance anatomical delineation of bony structures in the area of the tympanic cavity, a small series of rats were scanned by CT ( Fig. 4 E ). As can be seen on the CT images, part of the pathway of the ICA is hidden in the bony carotid canal ( Fig. 4 E ). The field of view of the 3D T1-weighted MRIs typically included the ICA and external carotid artery at the point of bifurcation ( Fig. 4 G , J ). Nevertheless, on the T1-weighted MRIs, the exact anatomical identification of vessels on the neck was not optimized for this purpose, although blood (in vessels with fast flow) will appear brighter than other adjacent structures and it is not possible with certainty to identify the anatomical structure that support CSF efflux along the ICA. However, our previous studies have shown that fluorescently tagged CSF tracers enter cervical lymph vessels and that this pathway constitutes an important drainage path for biomarkers of traumatic brain injury ( Atalaye Lacoste 5cxRt2
).

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Nov 30th 2017, 3:56 from Print edition

The government has crushed the opposition. Dealing with its creditors will be harder

Busted flush: Venezuela seeks the restructuring of its massive foreign debts

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But the president’s mysterious announcement raises more questions than it answers

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